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Principal Investigator

M Spite headshot 2024

Matthew Spite, Ph.D.
Associate Professor of Anaesthesia
Harvard Medical School

Lead Investigator
Center for Experimental Therapeutics and Reperfusion Injury (CETRI), Department of Anesthesiology, Perioperative and Pain Medicine
Brigham and Women’s Hospital.

Dr. Spite’s research focuses on the role of lipid mediators in the regulation of inflammation and its resolution. He contributed to the structural elucidation of lipid mediators that promote the resolution of acute inflammation (i.e., resolvin D2 and maresin 1) and maintains an active independent research program that seeks to understand the role of these pro-resolving mediators and their receptors in innate immunity, vascular biology, and tissue repair. His group is also interested in understanding whether defects in pro-resolution pathways contribute to chronic inflammation in cardiovascular and metabolic diseases, and whether pro-resolving mediators could be used as templates to develop novel therapeutics for chronic inflammatory diseases.

Lab Members

Hebe Agustina Mena

Hebe Agustina Mena, Ph.D.
Postdoctoral Fellow

Agustina completed her PhD at the Laboratory of Experimental Thrombosis, IMEX-ANM-CONICET, Argentina with the direction of Soledad Negrotto and fulfilled a research stay at the Université Paris Descartes, Paris. She also did a Postdoctoral training under the mentorship of Eugenio Carrera Silva. She joined the Spite Lab as a Postdoctoral Fellow in 2020.

Blenda Wong

Blenda Wong
Laboratory Manager

Blenda earned her Bachelor of Science Degree in Biochemistry from Tufts University in Medford, MA. She worked as a Research Associate at the Prince of Wales Hospital, Chinese University of Hong Kong, and Hong Kong Baptist University, before joining the Spite Lab in 2014.

Jake Altomare

Jake Altomare
Research Technician

Jake earned his Bachelor of Science degree in Biochemistry from Boston College in 2022 and joined the Spite Lab as a Research Technician.


Mary Walker, Ph.D., Postdoctoral Fellow (2021-2023). Currently Program Manager, LGC Group, London, U.K.

Filippa Davidsson, Summer Research Assistant (2021 and 2022). Currently Site Coordinator, Cebra Research, Ghent, Belgium

Heidi Yin, Technical Research Assistant (2020-2021). Currently Law Student, University of Michigan Law School, Ann Arbor, MI

Brian Sansbury, Ph.D., Postdoctoral fellow and Instructor (2014-2020). Currently Assistant Professor of Medicine, University of Louisville School of Medicine, Louisville, KY

Colin Riley, M.S., Technical Research Assistant (2018-2020). Currently Medical Student, UMass Chan Medical School, Worcester, MA

Xiaofeng Li, Ph.D., Postdoctoral Fellow (2016-2019). Currently Senior Scientist, Sanofi, Cambridge, MA

Jason Hellmann, Ph.D., Postdoctoral Fellow (2010-2016). Currently Associate Professor of Medicine, University of Louisville School of Medicine, Louisville, KY

Michael J. Zhang, M.D., Ph.D., Graduate Student (2010-2014). Currently Cardiology Fellow, University of Minnesota, Minneapolis, MN

Yunan Tang, Ph.D., Postdoctoral Fellow (2010-2013). Currently Toxicologist, National Center for Toxicological Research, U.S. Food and Drug Administration.

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